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Quantifying Synaptic Nanostructure–Function Relationships in Defined Neural Circuits
Project description:
Neuronal synapses are remarkably heterogeneous and dynamic structures that vary widely in molecular composition, nanostructure, and signaling strength. This rich variety of synaptic properties is essential for the memory and computational capacity of neural circuits. Resolving the mechanisms that drive synapse diversification is thus crucial for understanding how neural circuits operate and adapt. Recent work from us and others revealed that the structure and function of synapses is not only determined by the number, but also the nanoscale organization of synaptic proteins. As such, activity-driven changes in synapse nanostructure can thus drive adaptive changes in synaptic strength. This project aims to resolve how heterogeneity in molecular nanostructure shapes the functional diversification of synapses in defined neural circuits. In this project, you will use an array of approaches, including CRISPR/Cas9 genome editing, viral vector technology, and quantitative super-resolution microscopy, to resolve synaptic protein complexes at high resolution in defined synapses in brain tissue.
The successful candidate will be a member of the MacGillavry lab that is part of the larger neuroscience community at the Center for Neurogenomics and Neuroscience Research (CNCR) at VU Amsterdam, The Netherlands. We are a diverse group of enthusiastic molecular neuroscientists studying the processes that control synaptic transmission and plasticity at various levels and using a variety of techniques and analysis tools that we developed.
We are looking for a highly motivated, critical, and creative candidate to join our group. The preferred candidate:
As a university, we strive for equal opportunities for all, recognising that diversity takes many forms. We believe that diversity in all its complexity is invaluable for the quality of our teaching, research and service. We are always looking for talent with diverse backgrounds and experiences. This also means that we are committed to creating an inclusive community so that we can use diversity as an asset.
We realise that each individual brings a unique set of skills, expertise and mindset. Therefore we are happy to invite anyone who recognises themselves in the profile to apply, even if you do not meet all the requirements.
A challenging position in a socially engaged organisation. At VU Amsterdam, you contribute to education, research and service for a better world. And that is valuable. So in return for your efforts, we offer you:
We also offer you attractive fringe benefits and regulations. Some examples:
About us
The CNCR in Amsterdam (see www.cncr.nl) participates in the Graduate School ONWAR (www.ONWAR.nl). This position will be in the Department of Molecular and Cellular Neuroscience
Faculty of Science
Working at the Faculty of Science means collaborating with students, lecturers and researchers who are focused on their field, yet have a broad view of the world. We are proud of a positive and inclusive workplace culture within the faculty, where we work together with great energy and a pragmatic attitude to tackle social challenges. At the Faculty of Science, scientists and students work on fundamental and complex societal issues for a sustainable, healthy and just future.
From forest fires to big data, from obesity to malnutrition, from helium to the universe and from genetics to medicine: our education and research cover the full breadth of science, from molecules to mankind. Our academic education and research are highly experimental, technical and interdisciplinary in nature. That is why we collaborate extensively with leading scientific institutes and industry. The faculty has more than 8,000 students studying in one of the 39 programms and employs more than 1,400 staff across 10 scientific departments, making us one of the largest science faculties in the Netherlands.
Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam stands for values-driven education and research. We are open-minded experts with the ability to think freely - a broader mind. Maintaining an entrepreneurial perspective and concentrating on diversity, significance and humanity, we work on sustainable solutions with social impact. By joining forces, across the boundaries of disciplines, we work towards a better world for people and planet. Together we create a safe and respectful working and study climate, and an inspiring environment for education and research. Learn more about our codes of conduct
We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 6,150 staff work at the VU and over 31,000 students attend academic education.
Diversity
Diversity is the driving force of VU Amsterdam. VU wants to be accessible and receptive to diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences and worldviews. We believe that trust, respect, interest and differences lead to new insights and innovation, to sharpness and clarity, to excellence and a broader understanding.
We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services.
Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community.
Are you interested in this position and do you believe that your experience will contribute to the further development of our university? In that case, we encourage you to submit your application.
Submitting a diploma and a reference check are part of the application process.
Applications received by e-mail will not be considered.
Acquisition in response to this advertisement is not appreciated.

Quantifying Synaptic Nanostructure–Function Relationships in Defined Neural Circuits
Project description:
Neuronal synapses are remarkably heterogeneous and dynamic structures that vary widely in molecular composition, nanostructure, and signaling strength. This rich variety of synaptic properties is essential for the memory and computational capacity of neural circuits. Resolving the mechanisms that drive synapse diversification is thus crucial for understanding how neural circuits operate and adapt. Recent work from us and others revealed that the structure and function of synapses is not only determined by the number, but also the nanoscale organization of synaptic proteins. As such, activity-driven changes in synapse nanostructure can thus drive adaptive changes in synaptic strength. This project aims to resolve how heterogeneity in molecular nanostructure shapes the functional diversification of synapses in defined neural circuits. In this project, you will use an array of approaches, including CRISPR/Cas9 genome editing, viral vector technology, and quantitative super-resolution microscopy, to resolve synaptic protein complexes at high resolution in defined synapses in brain tissue.
The successful candidate will be a member of the MacGillavry lab that is part of the larger neuroscience community at the Center for Neurogenomics and Neuroscience Research (CNCR) at VU Amsterdam, The Netherlands. We are a diverse group of enthusiastic molecular neuroscientists studying the processes that control synaptic transmission and plasticity at various levels and using a variety of techniques and analysis tools that we developed.
We are looking for a highly motivated, critical, and creative candidate to join our group. The preferred candidate:
As a university, we strive for equal opportunities for all, recognising that diversity takes many forms. We believe that diversity in all its complexity is invaluable for the quality of our teaching, research and service. We are always looking for talent with diverse backgrounds and experiences. This also means that we are committed to creating an inclusive community so that we can use diversity as an asset.
We realise that each individual brings a unique set of skills, expertise and mindset. Therefore we are happy to invite anyone who recognises themselves in the profile to apply, even if you do not meet all the requirements.
A challenging position in a socially engaged organisation. At VU Amsterdam, you contribute to education, research and service for a better world. And that is valuable. So in return for your efforts, we offer you:
We also offer you attractive fringe benefits and regulations. Some examples:
About us
The CNCR in Amsterdam (see www.cncr.nl) participates in the Graduate School ONWAR (www.ONWAR.nl). This position will be in the Department of Molecular and Cellular Neuroscience
Faculty of Science
Working at the Faculty of Science means collaborating with students, lecturers and researchers who are focused on their field, yet have a broad view of the world. We are proud of a positive and inclusive workplace culture within the faculty, where we work together with great energy and a pragmatic attitude to tackle social challenges. At the Faculty of Science, scientists and students work on fundamental and complex societal issues for a sustainable, healthy and just future.
From forest fires to big data, from obesity to malnutrition, from helium to the universe and from genetics to medicine: our education and research cover the full breadth of science, from molecules to mankind. Our academic education and research are highly experimental, technical and interdisciplinary in nature. That is why we collaborate extensively with leading scientific institutes and industry. The faculty has more than 8,000 students studying in one of the 39 programms and employs more than 1,400 staff across 10 scientific departments, making us one of the largest science faculties in the Netherlands.
Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam stands for values-driven education and research. We are open-minded experts with the ability to think freely - a broader mind. Maintaining an entrepreneurial perspective and concentrating on diversity, significance and humanity, we work on sustainable solutions with social impact. By joining forces, across the boundaries of disciplines, we work towards a better world for people and planet. Together we create a safe and respectful working and study climate, and an inspiring environment for education and research. Learn more about our codes of conduct
We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 6,150 staff work at the VU and over 31,000 students attend academic education.
Diversity
Diversity is the driving force of VU Amsterdam. VU wants to be accessible and receptive to diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences and worldviews. We believe that trust, respect, interest and differences lead to new insights and innovation, to sharpness and clarity, to excellence and a broader understanding.
We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services.
Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community.
Are you interested in this position and do you believe that your experience will contribute to the further development of our university? In that case, we encourage you to submit your application.
Submitting a diploma and a reference check are part of the application process.
Applications received by e-mail will not be considered.
Acquisition in response to this advertisement is not appreciated.





